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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Solvation and dynamic behavior of cyclodextrins in dimethyl sulfoxide solution
Toshiyuki Shikata1, Rintaro Takahashi, Takeshi Onji
1Department of Macromolecular Science, Osaka University, Toyonaka, Osaka 560-0043, Japan. shikata@chem.sci.osaka-u.ac.jp
Abstract:
High-frequency dielectric relaxation behavior up to 20 GHz was investigated for plain (alpha, beta, gamma) and (62 and 100%) methylated cyclodextrins, CDs, in dimethyl sulfoxide, DMSO, solution. Each hydrogen atom of OH groups of the CDs solvated a DMSO molecule for a residence time of 130-180 ps due to the hydrogen bond formation to an oxygen atom of DMSO, and a few DMSO molecules were included in cavities of the CDs for a while similar to the residence time. The overall rotational relaxation modes of solvated CDs were also observed depending on the effective sizes of the solvated CDs.
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