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Published on: August 25, 2014
Methadone intoxication in a child: toxic encephalopathy?
Marisol Anselmo1, António Campos Rainho, Maria do Carmo Vale
1Intensive Care Unit, Hospital de Dona Estefânia, Lisbon, Portugal.
Journal of Child Neurology
|September 15, 2006
Summary
Accidental methadone ingestion in a child caused severe brain swelling and coma. Prompt treatment with methylprednisolone and CSF drainage led to a successful recovery, marking the first reported case of synthetic opioid-induced encephalopathy.
Area of Science:
- Neurology
- Toxicology
- Pediatrics
Background:
- Methadone is a synthetic opioid used for opioid addiction treatment.
- Acute methadone intoxication can be lethal.
- Leukoencephalopathy has been reported following heroin inhalation.
Observation:
- A 3-year-old boy accidentally ingested methadone.
- The child presented with coma, obstructive hydrocephalus, cerebellar edema, and supratentorial lesions.
Findings:
- This case represents the first reported instance of encephalopathy linked to synthetic opioid intoxication.
- The patient experienced severe brain edema and hydrocephalus.
Implications:
- Early recognition and intervention are crucial for managing synthetic opioid toxicity in children.
- Methylprednisolone and cerebrospinal fluid external drainage can be effective treatments.
- This case highlights the potential neurotoxicity of synthetic opioids beyond traditional opioids.
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