Related Experiment Video

Updated: Jul 20, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

Stroke associated with Barth syndrome

Beau M Ances1, Joseph Sullivan, John B Weigele

  • 1Departments of Neuroscience and Radiology, University of California at San Diego, San Diego, CA, USA.

Journal of Child Neurology
|September 15, 2006
PubMed

Insights

Barth syndrome, a rare genetic disorder, can lead to serious cardiovascular events like stroke. Early stroke prevention strategies may be crucial for affected individuals.

Area of Science:

  • Genetics
  • Cardiology
  • Neurology

Background:

  • Barth syndrome is a rare X-linked genetic disorder.
  • It is characterized by dilated cardiomyopathy, neutropenia, growth retardation, and skeletal myopathy.
  • Cardiovascular complications are known manifestations of Barth syndrome.

Observation:

  • A case of acute stroke in a patient with Barth syndrome is presented.
  • The stroke required intra-arterial thrombolysis for treatment.
  • This highlights a potential severe neurological complication.

Findings:

  • Barth syndrome is associated with an increased risk of stroke.
  • Cardiovascular complications in Barth syndrome can manifest as cerebrovascular events.
  • Intra-arterial thrombolysis can be a viable treatment option for stroke in these patients.

Implications:

  • This case underscores the importance of recognizing stroke as a potential complication of Barth syndrome.
  • Proactive stroke prevention strategies, possibly including antithrombotic therapy, should be considered for patients with Barth syndrome.
  • Further research into the cardiovascular and neurological risks in Barth syndrome is warranted.

More Related Videos

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis07:34

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis

Published on: December 30, 2025

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...