Epilepsy and neuropsychologic deficit in a child with cerebellar astrocytoma

Sandra Strazzer1, Claudio Zucca, Isabella Fiocchi

  • 1IRCCS E. Medea, La Nostra Famiglia, via don Luigi Monza 20, 23842 Bosisio Parini, Lecco, Italy. sandrastrazzer@yahoo.it

Journal of Child Neurology
|September 15, 2006
PubMed

Insights

A pediatric cerebellar pilocytic astrocytoma presented atypically with seizures and developmental delays, not typical tumor symptoms. This case highlights the cerebellum's role in nonmotor functions, especially post-surgery.

Area of Science:

  • Pediatric Neurology
  • Neuro-oncology
  • Developmental Neuroscience

Background:

  • Cerebellar pilocytic astrocytomas typically present with symptoms of increased intracranial pressure and ataxia.
  • Epileptic seizures are an uncommon presenting symptom for focal cerebellar masses.

Observation:

  • A 32-month-old female exhibited cerebellar pilocytic astrocytoma with initial symptoms of epileptic seizures, psychomotor delay, and severe language delay.
  • This presentation contrasts with the usual onset of cerebellar tumors.

Findings:

  • Literature review identified few cases of cerebellar tumors presenting primarily with epileptic seizures.
  • The cerebellar pilocytic astrocytoma in this case was a focal, nondegenerative mass.

Implications:

  • The cerebellum plays a significant role in nonmotor functions in children, including language and cognition.
  • Understanding atypical presentations is crucial for early diagnosis and management of pediatric brain tumors.
  • Cerebellar function in nonmotor domains may be impacted by tumor resection, necessitating further investigation.

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...