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Related Experiment Video

Updated: Jul 20, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and

Luis Miguel Blanco-Colio1, Begoña Muñoz-García, Jose Luis Martín-Ventura

  • 1Vascular Research Laboratory, Fundación Jiménez Díaz, Autónoma University, Avenida Reyes Católicos 2, Madrid, Spain.

Atherosclerosis
|September 15, 2006
PubMed
Summary

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Moderate consumption of polyphenol-rich alcoholic beverages like red wine, brandy, and rum can reduce inflammation markers. This study found they prevent increased NF-kappaB activation and monocyte chemoattractant protein-1 release during a fat-enriched diet.

Area of Science:

  • Cardiovascular Research
  • Nutritional Science
  • Immunology

Background:

  • Epidemiological studies suggest ethanol intake may reduce cardiovascular mortality, partly due to antioxidant properties.
  • Nuclear factor-kappa B (NF-kappaB) is a key transcription factor in atherosclerosis development.
  • Monocyte chemoattractant protein-1 (MCP-1) plays a role in inflammatory processes.

Purpose of the Study:

  • To investigate the impact of different ethanol-containing beverages on NF-kappaB activation in peripheral blood mononuclear cells (PBMC).
  • To assess the effect of these beverages on circulating MCP-1 levels in healthy volunteers on a fat-enriched diet.

Main Methods:

  • Sixteen healthy volunteers consumed 16 g/m(2) of ethanol from red wine, spirits (vodka, rum, brandy), or no ethanol over 5 days, with a fat-enriched diet.

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Last Updated: Jul 20, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
08:37

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
09:15

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

  • Blood samples were analyzed before and after the 5-day period.
  • NF-kappaB activation was measured using electrophoretic mobility shift assay (EMSA).
  • Circulating MCP-1 levels were quantified using ELISA.

    • Main Results:

    • A fat-enriched diet alone increased NF-kappaB activation in PBMCs and elevated plasma MCP-1 levels.
    • Red wine, brandy, and rum consumption significantly inhibited NF-kappaB activation.
    • These polyphenol-rich beverages also led to a decrease in MCP-1 release.

    Conclusions:

    • Moderate intake of alcoholic beverages rich in polyphenols can attenuate inflammatory responses.
    • Consumption of red wine, brandy, and rum may reduce NF-kappaB activation and MCP-1 levels during a high-fat diet.
    • These findings support the anti-inflammatory effects of moderate alcohol consumption and its potential role in reducing cardiovascular mortality.