Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ryk: a novel Wnt receptor regulating axon pathfinding.

Thomas R Keeble1, Helen M Cooper

  • 1The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia. t.keeble@hfi.unimelb.edu.au

The International Journal of Biochemistry & Cell Biology
|September 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A scoping review of Support Interventions for Bystanders involved in Out-of-Hospital Cardiac Arrest.

Resuscitation·2026
Same author

High reproducibility of lipid core burden measurements with near-infrared spectroscopy and intravascular ultrasound imaging catheter.

International journal of cardiology. Heart & vasculature·2026
Same author

Pullback Pressure Gradient and Intravascular Imaging in Focal and Diffuse Coronary Disease: The Next Step in Precision PCI?

Circulation. Cardiovascular interventions·2026
Same author

Shock delivery alone overestimates real-world automated emergency defibrillation effectiveness in out-of-hospital cardiac arrest.

Resuscitation·2026
Same author

Acute Coronary Occlusion in NSTEMI Patients: Prevalence, Clinical Characteristics and the Potential Role of Artificial Intelligence.

Medicina (Kaunas, Lithuania)·2026
Same author

Coronary sinus reducer implantation for refractory angina: a national audit of UK practice.

Heart (British Cardiac Society)·2026

The Ryk receptor, a novel Wnt signaling component, is crucial for axon guidance and embryonic development. Ryk loss-of-function mice exhibit skeletal, craniofacial, and cardiac abnormalities, indicating broader biological roles.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Cell Signaling

Background:

  • Wnt signaling and Frizzled receptors regulate key developmental processes.
  • The Ryk receptor family represents novel Wnt receptors with diverse functions.
  • Ryk acts as a chemorepulsiv e axon guidance receptor in mammals and flies.

Purpose of the Study:

  • To review the structure and function of Ryk.
  • To focus on Ryk's role in axon guidance.
  • To explore Ryk's broader biological significance beyond axon guidance.

Main Methods:

  • Review of existing literature on Ryk structure and function.
  • Analysis of phenotypes in Ryk loss-of-function mouse models.
  • Examination of Ryk expression patterns in developing and adult tissues.

Related Experiment Videos

Main Results:

  • Ryk is essential for establishing major axon tracts during nervous system development.
  • Ryk loss-of-function mice display significant embryonic abnormalities.
  • Abnormalities include disruptions in skeletal, craniofacial, and cardiac development.

Conclusions:

  • Ryk's function extends beyond axon guidance, impacting multiple developmental processes.
  • Widespread Ryk expression suggests critical roles in both development and adult physiology.
  • Further research into Ryk's multifaceted roles is warranted.