Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Types

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...

Blood Typing

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...

The ABO Blood Group

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

LAMP-1 gene is overexpressed in high grade glioma.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2018

Same author

YKL-40 and cytokines - a New Diagnostic Constellation in Rheumatoid Arthritis?

Folia medica·2017

Same author

A comparative study of LAMPs and YKL-40 tissue expression in glial tumors.

Folia medica·2014

Same author

Glioblastoma multiforme classified as mesenchymal subtype.

Folia medica·2014

Same author

Psychological stress--cellular and molecular mechanisms.

Folia medica·2012

Same author

Expression of histo-blood group antigens in vertebrate gonads.

Acta biologica Hungarica·2010

Search research articles

Related Experiment Video

Updated: Jul 20, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

ABH histo-blood group antigens in human thymus involution.

Victoria S Sarafian¹, Tsvetana T Marinova

¹Department of Medical Biology, Medical University-Plovdiv, Plovdiv, Bulgaria. v_sarafian@yahoo.com

Archives of Medical Research

|September 15, 2006

Summary

Human histo-blood group antigens (HBGA) expression changes in the aging thymus. Epithelial cells retain HBGA, while lymphocytes show diminished reactivity, suggesting altered cell communication during thymus involution.

More Related Videos

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

Formation of Human Thymus Organoids in Three-Dimensional Fibrin Hydrogels

Formation of Human Thymus Organoids in Three-Dimensional Fibrin Hydrogels

Published on: October 4, 2024

Related Experiment Videos

Last Updated: Jul 20, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

Formation of Human Thymus Organoids in Three-Dimensional Fibrin Hydrogels

Formation of Human Thymus Organoids in Three-Dimensional Fibrin Hydrogels

Published on: October 4, 2024

Area of Science:

Immunology
Developmental Biology
Glycobiology

Background:

Human histo-blood group antigens (HBGA) are glycoproteins involved in cell differentiation and metastasis.
Epithelial cells (EC) express HBGA and are crucial in the thymocyte microenvironment.
The aging process significantly impacts thymus structure and function.

Purpose of the Study:

To investigate the expression pattern of ABH HBGA in the senile thymus.
To characterize the relationship between HBGA expression and thymus aging.

Main Methods:

Routine histology and immunohistochemical techniques were employed.
Thymus glands from senile and young individuals were analyzed.

Main Results:

Involuted thymus showed HBGA-positive epithelial cells amidst adipose tissue.
Stromal EC exhibited uniform cytoplasmic staining for ABH antigens.
Lymphocytes and Hassall's corpuscles in young thymus expressed HBGA, unlike in senile thymus.

Conclusions:

Age-related thymus involution involves altered ABH antigen expression in EC.
HBGA are crucial for EC-lymphocyte crosstalk during thymus aging.
Diminished lymphocyte HBGA reactivity in aged thymus may indicate impaired cell communication.