Palatal enlargement in chronic lymphocytic leukemia

Area of Science:

• Oncology
• Radiology
• Hematology

Background:

• Chronic lymphocytic leukemia (CLL) is a hematologic malignancy with diverse clinical manifestations.
• Palatal involvement is an exceptionally rare presentation of CLL, with limited documentation in non-radiological literature.

Observation:

• This study presents the first imaging description of palatal involvement in chronic lymphocytic leukemia.
• The observed palatal masses were characterized as smoothly lobulated and homogeneous.

Findings:

• The imaging findings of smoothly lobulated, homogeneous masses on the hard palate are indicative of potential palatal CLL.
• This represents a novel imaging-based diagnostic consideration for this rare manifestation.

Implications:

• Radiologists and clinicians should consider CLL in the differential diagnosis for patients presenting with such palatal masses.
• This imaging description may aid in earlier diagnosis and management of this rare CLL presentation.