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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Bioavailability: Overview01:13

Bioavailability: Overview

Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
Bioavailability: Overview01:17

Bioavailability: Overview

Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
Organic Compounds03:02

Organic Compounds

All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...

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Related Experiment Video

Updated: Jul 20, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

An integrated database of flavonoids.

Takashi Kinoshita1, Zsolt Lepp, Yoshichika Kawai

  • 1Institute of Health Biosciences, The University of Tokushima, Graduate School, Schomachi 1-78, Tokushima, 770-8505, Japan.

Biofactors (Oxford, England)
|September 15, 2006
PubMed
Summary

A new database integrates plant-derived and medicinal flavonoids, including structures and properties. Virtual screening predicts activities, aiding pharmaceutical research and drug discovery.

More Related Videos

Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.
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Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.

Published on: June 27, 2025

Related Experiment Videos

Last Updated: Jul 20, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.
04:54

Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.

Published on: June 27, 2025

Area of Science:

  • Biochemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Flavonoids are plant-derived polyphenolic compounds with diverse physiological activities.
  • Many existing drugs contain flavonoid-related chemical structures.
  • A comprehensive database of flavonoids, including structures and physicochemical parameters, is currently lacking.

Purpose of the Study:

  • To create a unified database of flavonoids from plant sources and medicinal compounds.
  • To provide chemical structures and physicochemical data relevant to flavonoid activity.
  • To demonstrate the utility of this database for pharmaceutical research through virtual screening.

Main Methods:

  • Compilation of flavonoid data from plant origins and medicinal applications.
  • Integration of chemical structures and physicochemical parameters.
  • Application of virtual screening for predicting biological activities against various targets.

Main Results:

  • A comprehensive database of flavonoids, merging plant and medicinal sources, has been established.
  • Physicochemical parameters relevant to biological activity have been incorporated.
  • Virtual screening successfully predicted potential activities of flavonoids against specified targets.

Conclusions:

  • The developed flavonoid database serves as a valuable resource for pharmaceutical research.
  • This database facilitates the identification of novel drug candidates and the understanding of structure-activity relationships.
  • Virtual screening using the database demonstrates its potential for accelerating drug discovery processes.