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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Genetics of SLE in mice
Dwight H Kono1, Argyrios N Theofilopoulos
1Department of Immunology/IMM3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. dkono@scripps.edu
Springer Seminars in Immunopathology
|September 15, 2006
Summary
Mouse models reveal diverse genes influencing Systemic Lupus Erythematosus (SLE) susceptibility and pathogenesis. These models are crucial for understanding the complex genetic landscape of lupus.
Area of Science:
- Immunogenetics
- Rheumatology
- Genomics
Background:
- Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a significant genetic component.
- Understanding the genetic underpinnings of SLE is crucial for developing targeted therapies.
Purpose of the Study:
- To review the contribution of mouse models to understanding the genetics of SLE.
- To highlight the insights gained from various mouse models in identifying lupus-associated genes and pathways.
Main Methods:
- Analysis of genetic studies in spontaneous, induced, and genetically engineered mouse models of SLE.
- Review of findings on gene identification, disease resistance, and susceptibility modification.
Main Results:
- Mouse models have identified a diverse array of genes influencing SLE susceptibility and resistance.
- Novel genes and pathogenic mechanisms contributing to lupus have been discovered through these models.
- These studies provide a foundational understanding of the genomic landscape affecting lupus.
Conclusions:
- Mouse models are indispensable tools for dissecting the complex genetics of SLE.
- Continued use of mouse models is vital for advancing our knowledge of lupus pathogenesis and identifying therapeutic targets.
