Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kindling in the posterior cingulate cortex: electrographic and behavioral characteristics.

L S Leung1, K A Boon

  • 1Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.

Electroencephalography and Clinical Neurophysiology
|August 1, 1990
PubMed
Summary

This study investigated electrical activity in rat brains during kindling stimulation. Stimulating white matter pathways near the cingulate cortex led to faster seizure development compared to grey matter stimulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal CA1 region--demonstration of antidromic dendritic spike and dendritic inhibition.

Brain research·2011
Same author

Surgical treatment of penile curvature.

Hong Kong medical journal = Xianggang yi xue za zhi·2006
Same author

Altered neurotrophin receptor function in the developing prefrontal cortex leads to adult-onset dopaminergic hyperresponsivity and impaired prepulse inhibition of acoustic startle.

Biological psychiatry·2004
Same author

Temporal lobe seizures alter the amplitude and timing of rat behavioral rhythms.

Epilepsy & behavior : E&B·2003
Same author

Increased dendritic excitability in hippocampal ca1 in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis.

Neuroscience·2003
Same author

Apical and basal orthodromic population spikes in hippocampal CA1 in vivo show different origins and patterns of propagation.

Journal of neurophysiology·2001

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Animal Models

Background:

  • The cingulate cortex plays a role in various brain functions, including motor control and emotion.
  • Understanding the mechanisms of seizure propagation is crucial for epilepsy research.

Purpose of the Study:

  • To investigate the effects of kindling stimulation in different regions of the rat cingulate cortex.
  • To compare seizure development rates and characteristics based on stimulation site.

Main Methods:

  • Electrical activity (ictal, postictal, interictal) was recorded in the posterior cingulate cortex and hippocampus of rats.
  • Kindling stimulations were applied to the cingulate cortex, with electrodes placed in either white matter or grey matter regions.
  • Seizure development was monitored by afterdischarge (AD) counts and motor sign observation.

Related Experiment Videos

Main Results:

  • Stimulation of white matter pathways (cingulum/corpus callosum) resulted in significantly faster kindling rates compared to grey matter (area 29) stimulation.
  • The 'white matter' group required an average of 4.6 ADs to reach bilateral forelimb clonus, versus 17.8 ADs for the 'grey matter' group.
  • EEG spike frequency and morphology in the cingulate cortex remained stable, and interictal spikes were infrequent.

Conclusions:

  • The cingulate cortex's rapid kindling rates may be attributed to its connections with motor and limbic structures, rather than its intrinsic circuitry.
  • White matter pathways within the cingulate cortex appear critical for accelerated seizure development in this model.