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Updated: Jul 20, 2026
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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
[Batroxobin in patients with ischemic stroke in the carotid system (the multicenter study)]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|September 16, 2006
Summary
Batroxobin, an adjuvant therapy, significantly improved motor function in patients recovering from ischemic stroke. This treatment, administered intravenously, demonstrated rapid efficacy and was well-tolerated by participants.
Area of Science:
- Neurology
- Pharmacology
Context:
- Ischemic stroke resulting from internal carotid artery pathology poses significant disability risks.
- Early intervention is crucial for improving patient outcomes after stroke.
Purpose:
- To evaluate the efficacy and tolerability of adjuvant batroxobin therapy in patients with hemispheric ischemic stroke.
- To assess the impact of batroxobin on clinical symptoms, particularly motor function.
Summary:
- A randomized placebo-controlled trial involved 90 patients who had experienced hemispheric ischemic stroke.
- Patients received either standard therapy or adjuvant intravenous batroxobin on specific days post-admission.
- The European Stroke Scale assessed patient status, revealing significant improvements in movement disorders with batroxobin.
Impact:
- Batroxobin demonstrates potential as an effective adjuvant treatment for ischemic stroke, particularly for improving motor deficits.
- The study highlights the defibrinating effect of batroxobin and its good tolerability in stroke patients.
- Findings suggest batroxobin can accelerate recovery and enhance functional outcomes in post-stroke care.
