[Degenerative disorders of the skeleton in elderly]

Skeletal degeneration such as osteoporosis and osteoarthritis increases morbidity and mortality of aged persons. It is associated with inflammation induced by micro particles from bone and cartilage matrices and reduction in bone quality that could be due to disturbance of regulatory function of bone mass and structure in response to mechanical loading. Deformity in the skeletons induced by osteoporosis and osteoarthritis is irreversible and accumulating. To establish the substantial methods to alleviate it, we need to know the effects of gonad hormone deficiency underlying in the diseases.