Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Species-specific clinical differences in Fusobacterium infections: association with malignancy and prognosis.

Anaerobe·2026
Same author

Donor site morbidity and patient satisfaction after arthroscopic superior capsule reconstruction using fascia lata autograft for irreparable rotator cuff tears.

Journal of shoulder and elbow surgery·2026
Same author

Dynamic screening strategies for the control of a prolonged vancomycin-resistant enterococci outbreak: A decade-long study in a Japanese tertiary hospital.

Epidemiology and infection·2026
Same author

Sevoflurane Sedation for High-Risk Airway Management in the Pediatric Intensive Care Unit Following Sclerotherapy for a Pediatric Cervical Lymphatic Malformation: A Case Report.

Cureus·2026
Same author

Tear Biomarkers of Topical Sirolimus in Meibomian Gland Dysfunction: A Randomized Trial.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Correction: Lineage replacement of coxsackievirus A10 in Vietnam associated with increased detection and altered disease severity grading of hand, foot, and mouth disease.

Archives of virology·2026

Related Experiment Video

Updated: Jul 20, 2026

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
18:40

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Published on: October 16, 2014

[Bone and joint infection].

Kazuhiko Matsushita1, Hiroyuki Shimizu, Moroe Beppu

  • 1Department of Orthopaedic Surgery, Kawasaki Municipal Tama Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 16, 2006
PubMed
Summary

Older adults face higher infection risks due to age-related immune dysfunction. This includes conditions like hematogenous osteomyelitis, septic arthritis, and tuberculous spondylitis, requiring careful diagnosis.

Area of Science:

  • Gerontology
  • Immunology
  • Infectious Diseases

Context:

  • Advanced age is associated with immune dysfunction, increasing infection susceptibility in older adults.
  • Specific infections like hematogenous osteomyelitis, iatrogenic septic arthritis, and tuberculous spondylitis are prevalent in this demographic.
  • Distinguishing tuberculous spondylitis from pyogenic spondylitis and vertebral metastasis is clinically significant.

Purpose:

  • To highlight the increased risk of infections in older adults due to age-related immune changes.
  • To identify key infectious conditions affecting the aging population, including bone and joint infections.
  • To emphasize the diagnostic challenges in differentiating various spinal infections in elderly patients.

Summary:

  • Older adults experience immune dysfunction, elevating their risk for infections.

More Related Videos

A Periprosthetic Joint Candida albicans Infection Model in Mouse
04:37

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Related Experiment Videos

Last Updated: Jul 20, 2026

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
18:40

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Published on: October 16, 2014

A Periprosthetic Joint Candida albicans Infection Model in Mouse
04:37

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

  • Conditions such as hematogenous osteomyelitis, iatrogenic septic arthritis, and tuberculous spondylitis are concerns in the aging population.
  • Accurate differential diagnosis for tuberculous spondylitis is crucial to differentiate from other spinal pathologies.

    • Impact:

    • Informing healthcare providers about the unique infectious disease risks in older adults.
    • Guiding clinical practice and diagnostic strategies for infections in geriatric patients.
    • Improving patient outcomes through timely and accurate diagnosis of serious infections in the elderly.