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Published on: October 17, 2025
Adaptive designs from the viewpoint of an academic biostatistician
1Institute of Medical Biometry and Epidemiology, Philipps-University Marburg, Germany. hsimbe@med.uni-marburg.de
Abstract:
This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'FDA's critical path initiative: A perspective on contributions of biostatistics' by Robert T. O'Neill, 'A regulatory view on adaptive/flexible clinical trial design' by H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence; and 'Confirmatory clinical trials with an adaptive design' by Armin Koch.
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