Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unravelling Ovarian Cancer: an analysis of the Influence of LRP1 and PAI1 Genetic Variations.

Biochemical genetics·2026
Same author

Genome-Edited Maize Expressing Two Native Genes Confers Broad-Spectrum Resistance to Northern Corn Leaf Blight.

Molecular plant pathology·2026
Same author

Interplay between NOD1 polymorphisms and gene expression in the pathogenesis of gallstone disease.

Molecular biology reports·2026
Same author

How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational Investigations.

Journal of chemical information and modeling·2025
Same author

Genetic impact of copy number variations on congenital heart defects: Current insights and future directions.

Global medical genetics·2025
Same author

Advances in Computational Approaches for Estimating Passive Permeability in Drug Discovery.

Membranes·2023

Related Experiment Video

Updated: Jul 20, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification.

Nandini Krishnamurthy1, Duncan P Brown, Dan Kirshner

  • 1Department of Bioengineering, 473 Evans Hall #1762, University of California, Berkeley, CA 94720, USA.

Genome Biology
|September 16, 2006
PubMed
Summary

PhyloFacts is a structural phylogenomic encyclopedia with nearly 10,000 protein family entries. It helps biologists avoid errors in protein function prediction by integrating diverse data within an evolutionary framework.

More Related Videos

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Related Experiment Videos

Last Updated: Jul 20, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Area of Science:

  • * Phylogenomics
  • * Structural Biology
  • * Bioinformatics

Background:

  • * Protein function prediction is crucial for biological research.
  • * Homology-based methods can introduce systematic errors.
  • * Integrating diverse data is necessary for accurate functional analysis.

Purpose of the Study:

  • * To present PhyloFacts, a comprehensive structural phylogenomic encyclopedia.
  • * To provide a resource for accurate protein function prediction.
  • * To enable biologists to avoid errors in functional inference.

Main Methods:

  • * Development of a structural phylogenomic encyclopedia ('PhyloFacts').
  • * Integration of experimental data and bioinformatics methods.
  • * Application of an evolutionary framework for analysis.

Main Results:

  • * PhyloFacts contains nearly 10,000 entries for protein families and domains.
  • * Pre-calculated structural, functional, and evolutionary analyses are available.
  • * The resource facilitates classification of user-submitted sequences.

Conclusions:

  • * PhyloFacts offers a robust framework for understanding protein evolution and function.
  • * The encyclopedia minimizes systematic errors in function prediction.
  • * It serves as a valuable web resource for the biological community.