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Updated: Jul 20, 2026

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
Published on: June 24, 2012
Mendelian resistance to human norovirus infections
Jacques Le Pendu1, Nathalie Ruvoën-Clouet, Elin Kindberg
1Inserm U601, University of Nantes, Institute of Biology, 9 Quai Moncousu, 44093 Nantes, Cedex 01, France. jlependu@nantes.inserm.fr
Abstract:
Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the alpha1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host-pathogen co-evolution driven by carbohydrate-protein interactions.
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