Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kinin receptor subtypes.

D Regoli1, N E Rhaleb, G Drapeau

  • 1Department of Pharmacology, Medical School, University of Sherbrooke, Canada.

Journal of Cardiovascular Pharmacology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice.

Neuroscience·2013
Same author

Therapeutic options in inflammatory bowel disease: experimental evidence of a beneficial effect of kinin B1 receptor blockade.

British journal of pharmacology·2008
Same author

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice.

British journal of pharmacology·2008
Same author

Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance.

Neuropeptides·2007
Same author

Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

The journal of peptide research : official journal of the American Peptide Society·2005
Same author

Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice.

Naunyn-Schmiedeberg's archives of pharmacology·2004

Bradykinin and kallidin effects are mediated by B1 and B2 receptors, but new research suggests subtypes and non-receptor pathways. Selective agonists and antagonists aid in characterizing these complex kinin receptor systems.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Physiology

Background:

  • Bradykinin and kallidin exert significant biological effects via B1 and B2 receptors.
  • Recent studies challenge the traditional receptor classification, proposing subtypes and novel receptor types (e.g., B3).
  • Kinins' actions can also involve non-receptor mediated pathways, such as prostaglandin and histamine release.

Purpose of the Study:

  • To review the current understanding of kinin receptor classification and function.
  • To highlight the development and application of novel kinin-related peptides, including selective agonists and antagonists.
  • To explore both receptor-mediated and non-receptor-mediated mechanisms of kinin action.

Main Methods:

  • Utilized synthetic analogs (agonists and antagonists) of bradykinin and kallidin.

Related Experiment Videos

  • Characterized receptor subtypes and potential new receptor types.
  • Investigated non-receptor mechanisms involved in kinin signaling.
  • Employed selective agonists and antagonists for receptor characterization in biological systems.

    • Main Results:

    • New selective agonists for B1 and B2 receptors have been identified.
    • Pure antagonists have been developed and used for receptor characterization.
    • Evidence supports the existence of B2-receptor subtypes and potentially new receptor types.
    • Kinins activate both receptor and non-receptor pathways, leading to diverse cellular effects.

    Conclusions:

    • The classification of kinin receptors is evolving, with evidence for subtypes and novel receptors.
    • Selective pharmacological tools are crucial for dissecting complex kinin signaling pathways.
    • Kinins' biological effects are mediated through a combination of receptor-dependent and independent mechanisms.