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An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples
Published on: April 12, 2015
Concise review: multipotent mesenchymal stromal cells in blood
1Centre for Cancer Research and Cell Biology, Musculoskeletal Education and Research Unit, School of Biomedical Sciences, Queen's University of Belfast, Musgrave Park Hospital, Belfast, United Kingdom.
Stem Cells (Dayton, Ohio)
|September 16, 2006
Summary
Peripheral blood mesenchymal stromal cells share markers with bone marrow cells but have unique gene expression. Their presence suggests potential systemic migration and common stem cell precursors.
Area of Science:
- Stem Cell Biology
- Hematology
Background:
- Peripheral blood contains multipotent mesenchymal stromal cells (MSCs) in low numbers.
- These cells share surface markers with bone marrow-derived MSCs but exhibit distinct gene expression.
- Their origin and physiological roles remain largely undefined.
Purpose of the Study:
- To summarize current knowledge on peripheral blood-derived MSCs.
- To discuss their potential implications in stem cell biology, including migration and precursor existence.
Main Methods:
- Review of existing scientific literature and studies.
- Comparative analysis of peripheral blood-derived MSCs and bone marrow-derived MSCs.
- Discussion of controversial topics in adult stem cell research.
Main Results:
- Peripheral blood MSCs exhibit partial overlap in surface markers with bone marrow MSCs.
- These cells possess complex and diverse gene expression profiles.
- They demonstrate differentiation capacity along and beyond mesenchymal lineages.
Conclusions:
- The presence of MSCs in adult peripheral blood raises questions about stem cell migration and common precursors.
- Further research is needed to clarify the origin and function of peripheral blood MSCs.
- These cells are relevant to ongoing debates in adult stem cell biology.
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