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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

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Published on: February 1, 2012

Colitis due to Ancylostoma duodenale.

Varghese Thomas1, K Harish, J Tony

  • 1Department of Gastroenterology, Medical College Hospital, Calicut-673 008, India. dr_harishk@yahoo.co.in

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|September 16, 2006
PubMed
Summary

Hookworm infestation in the colon is a previously unreported condition. A patient with bloody diarrhea recovered after treatment with mebendazole for colonic hookworms.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Parasitology

Background:

  • Hookworm larvae mature into adults in the small intestine.
  • Chronic intestinal blood loss and iron-deficiency anemia are common complications of hookworm infection.
  • Colonic hookworm infestation has not been previously documented in medical literature.

Observation:

  • A 35-year-old male presented with symptoms of diarrhea, blood, and mucus in stools.
  • Colonoscopy identified multiple hookworms attached to the colonic mucosa.
  • The attached hookworms caused visible bleeding and erosion of the surrounding tissue.

Findings:

  • The case represents the first reported instance of hookworm infestation within the colon.
  • The colonic mucosa showed signs of trauma and blood loss due to the parasites.
  • Mebendazole treatment led to complete resolution of the patient's symptoms.

Implications:

  • This finding expands the known clinical spectrum of hookworm disease.
  • It highlights the importance of considering hookworm infection in patients with unexplained gastrointestinal bleeding, even in the colon.
  • Further research may be warranted to understand the prevalence and pathogenesis of colonic hookworm infections.