Related Experiment Video
Updated: Jul 20, 2026
07:30
Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
Published on: June 28, 2024
Primary transitional cell carcinoma of spleen
Saleem Naik1, Sorabh Kapoor, Sandesh Sharma
1Department of Gastrointestinal Surgery, Bhopal Memorial Hospital and Research Center, Raisen Bypass Road, Karond, Bhopal 462-038, India.
Summary
Transitional cell carcinoma, typically found in the urinary tract, was identified in the spleen of a 39-year-old woman. This rare case highlights the spleen as an unusual site for this cancer, with the patient recovering well post-surgery.
Area of Science:
- Uropathology
- Oncology
- Surgical Pathology
Background:
- Transitional cell carcinoma (TCC) commonly originates from the urothelium lining the urinary tract and the ovary.
- Metastatic or primary splenic tumors are rare, with TCC of the spleen being exceptionally uncommon.
Observation:
- A 39-year-old female presented with a complex cystic lesion in the spleen.
- Diagnostic investigations ruled out other primary tumor sites.
Findings:
- The splenic lesion was diagnosed as transitional cell carcinoma.
- The patient underwent a successful splenectomy.
Implications:
- This case expands the known anatomical distribution of transitional cell carcinoma.
- Highlights the importance of considering rare diagnoses in complex splenic lesions.
- Demonstrates favorable outcomes following surgical management of splenic TCC.
Related Concept Videos
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...