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Related Experiment Videos

Mouse models of otitis media.

Carol J MacArthur1, Dennis R Trune

  • 1Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239-3098, USA. macarthc@ohsu.edu

Current Opinion in Otolaryngology & Head and Neck Surgery
|September 16, 2006
PubMed
Summary

The mouse model is emerging as a preferred choice for studying acute otitis media (AOM) in children. Its genetic manipulability and well-understood immune system make it ideal for understanding AOM mechanisms and developing new treatments.

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Area of Science:

  • Pediatric inflammatory diseases
  • Microbiology and immunology
  • Animal modeling for human diseases

Background:

  • Otitis media (OM) is a common pediatric inflammatory condition with substantial personal and societal costs.
  • Antibiotic-related issues necessitate research into novel prevention and treatment strategies for acute otitis media (AOM).
  • Animal models are crucial for elucidating AOM mechanisms and exploring new therapeutic avenues.

Purpose of the Study:

  • To review the utility of animal models in understanding acute otitis media (AOM).
  • To highlight the advantages of the mouse model for AOM research.
  • To assess the suitability of the mouse model for genetic and molecular investigations of AOM.

Main Methods:

  • Induction of AOM in various animal models through bacterial components or direct injection.

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  • Focus on the mouse model due to its genetic tractability and immunological characteristics.
  • Leveraging available reagents and extensive genomic data for in-vivo studies.

    • Main Results:

    • The mouse model offers significant advantages for in-vivo research, including ease of genetic modification.
    • Availability of diverse mouse strains and well-characterized immune systems facilitates detailed study.
    • Extensive knowledge of the mouse genome supports genetic and molecular investigations of AOM.

    Conclusions:

    • The mouse model accurately reflects human AOM, supported by accumulating data.
    • Increased availability of knockout and transgenic mice enhances its utility.
    • The mouse model is increasingly recognized as a model of choice for AOM research.