Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
Bode Plots Construction01:24

Bode Plots Construction

The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):
Ohm's Law01:19

Ohm's Law

Resistors are fundamental components in electrical circuits, often manufactured from metallic alloys or carbon compounds. They model a material's ability to resist the flow of electric current, a characteristic that is crucial in controlling and regulating electrical power within a circuit.
This current-resisting behavior of resistors is governed by Ohm's law, which states that the voltage across a resistor is directly proportional to the current flowing through it.
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing Large Language Models for Early Article Identification in Otolaryngology-Head and Neck Surgery Systematic Reviews.

Health care science·2026
Same author

Pressure-induced ossicular alterations in the oim mouse model of brittle bone disease do not cause hearing loss.

Hearing research·2026
Same author

Effect of bisphosphonate treatment on the oim mouse middle ear ossicles' structure, composition and hearing.

Bone·2025
Same author

Sex-specific hearing loss in Sirt3 knockout mice and attenuation by honokiol.

Hearing research·2025
Same author

ALZET pump implantation in mice for chronic drug delivery to the cochlea.

Scientific reports·2025
Same author

Optical method to preserve residual hearing in patients receiving a cochlear implant.

Frontiers in audiology and otology·2025

Related Experiment Video

Updated: Jul 20, 2026

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
08:51

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

Tissue resistivities determine the current flow in the cochlea.

Alan Gerard Micco1, Claus-Peter Richter

  • 1Northwestern University Feinberg School of Medicine, Department of Otolaryngology-Head and Neck Surgery, The Hugh Knowles Center, Chicago, Illinois , USA. agm109@northwestern.edu

Current Opinion in Otolaryngology & Head and Neck Surgery
|September 16, 2006
PubMed
Summary

Cochlear implants stimulate spiral ganglion cells, similar to normal hearing. Understanding current spread in the cochlea is key to improving electrode-tissue interface performance for better hearing outcomes.

More Related Videos

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
09:53

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

Related Experiment Videos

Last Updated: Jul 20, 2026

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
08:51

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering
09:53

A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering

Published on: January 1, 2018

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Otolaryngology

Background:

  • Cochlear implants bypass damaged inner ear structures to restore hearing in severe to profound hearing loss.
  • Electrical stimulation of spiral ganglion cells mimics acoustic frequency band encoding in normal hearing.

Purpose of the Study:

  • To review challenges related to current spread and nonselective stimulation of spiral ganglion cells in cochlear implant users.
  • To explore how cochlear anatomy and tissue properties influence current propagation.

Main Methods:

  • Review of existing literature on cochlear implant function and current spread.
  • Analysis of factors affecting electrical current pathways within the cochlea.

Main Results:

  • Cochlear anatomy and tissue properties dictate current flow, primarily through the scala tympani and across cochlear turns.
  • Natural current escape routes include the modiolus, facial canal, and round window.
  • Degenerative processes can alter tissue resistivity, impacting current spread.

Conclusions:

  • Optimizing electrode design and coding strategies can enhance spatial stimulation of spiral ganglion cells.
  • Improved electrode-tissue interface performance is achievable through refined stimulation techniques.