Visual evoked potentials in Alzheimer's disease: correlations with age and severity

Flash and pattern reversal visually evoked potentials were recorded in 25 patients fulfilling NINCDS-ADRDA criteria for 'probable' Alzheimer's disease (AD). Results were compared with those obtained from groups of normal elderly subjects and patients with mild memory impairment not amounting to dementia. The P2 component of the flash VEP was significantly delayed in AD patients of 74 years or less and correlated with severity whereas the P100 component of the pattern reversal VEP remained relatively unchanged. The latency difference between the P2 and the P100 proved to be a valid discriminator between demented and non-demented subjects only in the younger age group. This limits its usefulness as a diagnostic test of dementia in patients over the age of 75.