[Thyroid hormone dynamics during the thyrostatic treatment of Basedow's disease]

The efficacy of the generally accepted therapeutic scheme was studied in 52 newly discovered and untreated patients with Basedow's disease with the purpose to clarify the frequent failures of the thyrostatic treatment. The thyroid hormones levels were determined in dynamics initially and in the course of the disease. The results show that the efficacy of the thyrostatic drugs is individually different and depends on the supersensitivity of the thyroid gland. The remission occurred on the average on the 50th day--considerably earlier than the usually expected time limit. In order to study the expedience of the therapeutic scheme applied, the active dose required by the scheme was continued. As a result in the 4 month after the beginning of the treatment the thyrotropic hormone increased to a mean level of 35.7 mU/l--hypothyroid value. A monthly control of the thyroid hormones levels during the course of the active treatment is necessary and a reduction of the doses of the thyrostatic drugs when a remission is achieved must be performed.