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Updated: Jul 20, 2026
09:48
Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
Published on: September 26, 2019
Collagenase and surgical disease
Timothy R Donahue1, Jonathan R Hiatt, Ronald W Busuttil
1Division of General Surgery, David Geffen School of Medicine at UCLA, Box 956904, 72-160 CHS, Los Angeles, CA 90095-6904, USA.
Hernia : the Journal of Hernias and Abdominal Wall Surgery
|September 16, 2006
Summary
Collagenase, an enzyme degrading extracellular matrix proteins, plays a key role in tissue repair. Its dysregulation is linked to diseases like aortic aneurysms and cancer metastasis.
Area of Science:
- Biochemistry
- Cell Biology
- Pathology
Background:
- Collagen types I, II, and III are the primary extracellular matrix (ECM) proteins.
- Collagenase, a matrix metalloproteinase (MMP), is crucial for collagen degradation.
- Cellular-ECM interactions are fundamental for tissue integrity and function.
Purpose of the Study:
- To review the role of collagenase in ECM remodeling and repair.
- To highlight the involvement of collagenase in various disease states.
- To identify collagenase as a potential therapeutic target.
Main Methods:
- Literature review of recent research on collagenase.
- Analysis of collagenase's role in ECM remodeling and repair processes.
- Examination of disease states associated with altered collagenase activity.
Main Results:
- Collagenase is central to ECM remodeling and tissue repair mechanisms.
- Aberrant collagenase expression or function is implicated in aortic aneurysms, tumor invasiveness, metastasis, and hernias.
- Collagenase activity is significantly altered in numerous pathological conditions.
Conclusions:
- Collagenase is intrinsically involved in the pathophysiology of many surgical diseases.
- Targeting collagenase presents a promising therapeutic strategy for diseases involving ECM dysregulation.
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