Related Experiment Video
Updated: Jul 20, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
Published on: April 17, 2020
Progress in legal definition of brain death and consent to remove cadaver organs
1Department of Surgery, University of Chicago, Chicago, Ill 60637, USA.
Insights
Brain death legal definitions are crucial for organ donation, particularly kidney transplants. Standardized medical criteria are essential for declaring brain death and maximizing the availability of viable organs.
Area of Science:
- Medical Law
- Nephrology
- Transplantation Immunology
Background:
- The demand for cadaver kidneys for transplantation significantly exceeds the available supply.
- Kidneys from donors with fatal head injuries or strokes, declared brain dead, offer the least ischemic injury.
- Establishing legal clarity around brain death is vital to increase the pool of transplantable organs.
Purpose of the Study:
- To clarify the legal status of brain death to facilitate organ salvage.
- To encourage the retrieval of transplantable kidneys with minimal ischemic injury.
- To review the evolution of state laws defining brain death and proposed model legislation.
Main Methods:
- Analysis of state legislation codifying the concept of brain death.
- Review of model laws proposed by the American Bar Association (ABA) and the Institute of Society, Ethics and Life Sciences.
- Examination of medical criteria for determining brain death, including electrocerebral silence and confirmatory tests for absent cerebral blood flow.
Main Results:
- Twelve states have codified the concept of brain death into law.
- Recent state laws increasingly adopt simpler ABA-proposed models for defining brain death.
- Medical groups, like the NIH-supported Collaborative Study on Cerebral Survival, are defining specific diagnostic criteria.
Conclusions:
- Standardized legal definitions of brain death are essential for improving organ transplantation rates.
- The ABA model law offers a simplified framework for future state legislation.
- Consensus on medical criteria, including electroencephalogram (EEG) and cerebral blood flow studies, is critical for accurate brain death determination.
Abstract:
The availability of cadaver kidneys for transplantation falls far short of the needs of a rapidly expanding population of patients on chronic hemodialysis. Kidneys with the least ischemic injury come from donors with fatal head injury or stroke; such kidneys can be removed from a "beating-heart" cadaver after declaring death on the basis of brain death. To clarify the legal status of brain death and to encourage salvage of transplantable kidneys with minimal ischemic injury, 12 states already have codified the concept of brain death. Although the first few laws were lengthy and included medical terms, six of the last seven laws have used one or two models proposed by the American Bar Association (ABA) and the Institute of Society, Ethics and Life Sciences, Hastings-on-Hudson, N. Y. The ABA proposal is the simpler of the two models and should provide the basis for future state laws. In addition, the National Conference of Commissioners on Uniform State Laws plans to present a model law to define death and the liabilities of a physician who declares death on the basis of brain death by mid 1977. While state legislatures have written laws that establish the legality of the concept of brain death, medical groups have sought to define the medical criteria for its determination. The most recent list of criteria comes from a National Institutes of Health-supported Collaborative Study on Cerebral Survival, as follows: (1) unresponsivity, (2) apnea, (3) dilated pupils and absent cephalic reflexes, (4) electrocerebral silence, (5) a confirmatory test of absent cerebral blood flow (angiography, isotope bolus curve, retinoscopy, or echoencephalography).
Related Concept Videos
Psychosurgery
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Kidney Transplant I: Introduction

