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Urinary excretion of cyclic AMP in primary hyperparathyroidism
Australian and New Zealand Journal of Medicine
|February 1, 1975
Summary
Patients with primary hyperparathyroidism (PHPT) show elevated urinary cyclic adenosine monophosphate (cyclic AMP) levels. This biomarker can help diagnose PHPT, especially in cases with normal calcium levels or kidney issues.
Area of Science:
- Endocrinology
- Urology
- Biochemistry
Background:
- Primary hyperparathyroidism (PHPT) is a condition characterized by excessive parathyroid hormone secretion.
- Assessing urinary biomarkers can aid in the diagnosis and management of endocrine disorders.
- Cyclic adenosine monophosphate (cyclic AMP) plays a role in various cellular signaling pathways.
Purpose of the Study:
- To investigate urinary cyclic adenosine monophosphate (cyclic AMP) levels in patients with primary hyperparathyroidism (PHPT).
- To determine if urinary cyclic AMP can serve as a diagnostic marker for PHPT.
- To evaluate the changes in urinary cyclic AMP following parathyroidectomy.
Main Methods:
- Competitive protein binding assay was used to measure urinary cyclic AMP.
- Study included 19 patients diagnosed with PHPT and 15 healthy control subjects.
- Urinary cyclic AMP was measured over a 24-hour period.
Main Results:
- Mean urinary cyclic AMP excretion was significantly higher in PHPT patients (6.6 +/- 0.64 muM/24h) compared to controls (3.2 +/- 0.24 muM/24h) (P < 0.001).
- Hypercalcaemic PHPT patients without renal insufficiency consistently showed urinary cyclic AMP > 4 muM/24h.
- Urinary cyclic AMP levels decreased after parathyroidectomy in 15 investigated patients.
Conclusions:
- Elevated urinary cyclic AMP is a characteristic finding in primary hyperparathyroidism.
- Urinary cyclic AMP measurement is a valuable tool for diagnosing PHPT, even in normocalcaemic patients or those with renal insufficiency.
- Post-parathyroidectomy, urinary cyclic AMP levels normalize, supporting its role as a biomarker.