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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: Jun 30, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Cellular search migrations in normal development and carcinogenesis.

J M Vasiliev1, I M Gelfand

  • 1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia. yuvasiliev@yahoo.com

Biochemistry. Biokhimiia
|September 19, 2006
PubMed
Summary
This summary is machine-generated.

Search migrations are essential morphogenetic processes involving cell movement and differentiation. Aberrations in these cell migration pathways are linked to cancer invasion, where cells fail to stop and differentiate.

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cancer Biology

Background:

  • Morphogenetic processes guide cell movement and differentiation during development.
  • Cell migration is fundamental for tissue formation and organogenesis.
  • Understanding normal cell migration is crucial for deciphering developmental processes and diseases.

Purpose of the Study:

  • To review the concept and stages of search migrations.
  • To explore the role of search migrations in normal development.
  • To examine the link between aberrant search migrations and cancer cell invasion.

Main Methods:

  • Literature review of morphogenetic processes.
  • Analysis of cell migration mechanisms.
  • Comparison of normal and cancer cell migration.

Main Results:

  • Search migrations involve distinct 'search' and 'choice' phases.
  • Cells migrate through cell-free spaces and stop at specific loci for differentiation.
  • Failure to complete the 'choice' stage leads to apoptosis or aberrant behavior.
  • Cancer cell invasion represents a genetic aberration of normal search migration.

Conclusions:

  • Search migrations are a fundamental biological process with two key stages.
  • Disrupted search migrations contribute to pathological conditions like cancer.
  • Further research into cell migration control mechanisms is warranted.