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Point mutations in protein globular domains: contributions from function, stability and misfolding

I E Sánchez1, J Tejero, C Gómez-Moreno

  • 1European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. ignacio.sanchez@embl.de

Journal of Molecular Biology
|September 19, 2006
PubMed
Summary

Protein evolution prioritizes function over stability at catalytic sites, with stability playing a minor role at binding sites. Misfolding avoidance is primarily achieved by stabilizing native states, not by discarding misfolding-prone sequences.

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