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Updated: Jul 1, 2026
Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Mean-field coupling of calcium oscillations in a multicellular system of rat hepatocytes
1Department of Physics and Institute of Biophysics, Central China Normal University, Wuhan 430079, China. wud@phy.ccnu.edu.cn
Abstract:
In a multicellular system of rat hepatocytes and even in an intact liver, cytoplasmic calcium oscillations are synchronized and highly coordinated. In this paper, the mean-field coupling term has been introduced to describe the coupling flux, which is more efficient than gap junctional coupling terms. An optimal coupling strength and an optimal stimulation level for the synchronization of the coupled system have been observed in this paper. Moreover, it has been proved that these results are independent of the cells number. Interestingly, it has been observed that the intracellular noise and the extracellular noise have different effects on the synchronization of the coupled system.
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