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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Erk pathways negatively regulate matrix mineralization

Shin-jiro Kono1, Yasushi Oshima, Kazuto Hoshi

  • 1Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

Bone
|September 19, 2006
PubMed
Summary

The extracellular signal-regulated kinase (Erk) pathway negatively regulates skeletal matrix mineralization. Inhibiting Erk enhances bone mineralization, while activating it suppresses this crucial process.

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