Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostate specific antigen and local recurrence after radical prostatectomy.

D J Lightner1, P H Lange, P K Reddy

  • 1Department of Urologic Surgery, University of Minnesota Hospital and Clinic, Minneapolis.

The Journal of Urology
|October 1, 1990
PubMed
Summary

Prostate specific antigen (PSA) levels effectively detect early prostate cancer recurrence after radical prostatectomy. Digital rectal exams are less reliable for identifying local disease in these patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining constructs of high-quality rural health student placements: a multiple case ECOUTER study.

BMC health services research·2026
Same author

Validation of a stall-side immunoglobulin assay for use in equine reproductive management.

Equine veterinary journal·2026
Same author

Dynamic infrared aurora on Jupiter.

Nature communications·2025
Same author

Multi-disciplinary mass burn casualty simulation exercise.

Burns : journal of the International Society for Burn Injuries·2024
Same author

Delivering Care for Pregnant Women with Rheumatic and Musculoskeletal Diseases.

Irish medical journal·2024
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Area of Science:

  • Urology
  • Oncology
  • Medical Diagnostics

Background:

  • Radical prostatectomy is a common treatment for prostate cancer.
  • Monitoring for disease recurrence after surgery is crucial.
  • Prostate specific antigen (PSA) is a key biomarker for prostate cancer.

Observation:

  • This study evaluated 63 patients with elevated PSA levels post-prostatectomy.
  • Standard diagnostic methods (imaging, cystoscopy, DRE) were compared with anastomotic biopsies.
  • Patients with normal PSA levels served as a control group.

Findings:

  • Elevated PSA levels indicated local recurrence in 42% of patients undetectable by standard methods.
  • Metastatic disease was found in 6 patients, and local recurrence in 5.

Related Experiment Videos

  • No local disease was detected in patients with normal PSA levels post-surgery.

    • Implications:

    • Prostate specific antigen testing is a superior early indicator of local recurrence compared to digital rectal examination.
    • Routine anastomotic biopsies guided by PSA levels may improve detection rates of post-prostatectomy recurrence.
    • Further research is needed to establish the precise prevalence and management of local recurrence detected by PSA and biopsy.