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Updated: Jul 20, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Overview of dosimetry for Systemic Targeted Radionuclide Therapy (STaRT)
Barry W Wessels1, Joseph H Syh, Ruby F Meredith
1Department of Radiation Oncology, Comprehensive Cancer Care Center, Case Western Reserve University, Cleveland, OH, USA. Wessels@uhhs.com
Abstract:
The purposes of systemic targeted radionuclide therapy dosimetry include compiling a database of normal organ radiation-absorbed doses that are carrier- and radionuclide-specific, and assuring that the normal organ radiation doses are within a safe range before therapy. Also of importance is quantitation of radiation delivery to tumors vs. normal tissues to correlate absorbed dose with tumor control. For agents with significant and variable excretion, estimates of individual patient distribution/clearance may be needed to optimize the dose-response relationship.
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