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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
Cure of incurable lymphoma
Gerald L DeNardo1, Vladimir V Sysko, Sally J DeNardo
1Radiodiagnosis and Therapy, Division of Hematology/Oncology, University of California Davis Medical Center, Sacramento, CA, USA. gldenardo@ucdavis.edu
International Journal of Radiation Oncology, Biology, Physics
|September 19, 2006
Summary
Radioimmunotherapy (RIT) enhances cancer treatment by attaching radionuclides to monoclonal antibodies (MAbs). This approach shows significant potential for improving outcomes in B-cell non-Hodgkin
Area of Science:
- Oncology
- Radiochemistry
- Immunotherapy
Background:
- Monoclonal antibody (MAb) therapy can be significantly enhanced by conjugating radionuclides for targeted systemic radiotherapy, known as radioimmunotherapy (RIT).
- The efficacy of RIT is influenced by multiple factors including the antigen-MAb interaction, radionuclide choice, radiochemistry, chelator, and linker technology.
- Alternative strategies like smaller antibody fragments, mimics, and pretargeting are being explored to optimize RIT delivery and effectiveness.
Purpose of the Study:
- To review the critical components and evolving strategies in radioimmunotherapy for cancer treatment.
- To highlight the potential of RIT as a therapeutic option for B-cell non-Hodgkin's lymphoma (NHL).
Main Methods:
- Review of existing literature on radioimmunotherapy components and strategies.
- Evaluation of factors influencing radiopharmaceutical performance in RIT.
- Assessment of RIT's applicability and potential in B-cell non-Hodgkin's lymphoma management.
Main Results:
- Various components of RIT, including antibody selection, radionuclide, and linker chemistry, critically impact drug performance.
- Optimized drug design and novel strategies like pretargeting offer improved therapeutic potential.
- RIT demonstrates promise for enhancing patient outcomes in B-cell NHL.
Conclusions:
- Radioimmunotherapy is a potent method for augmenting MAb-based cancer therapy.
- Improvements in RIT drugs and strategies are expected to enhance patient outcomes, particularly in B-cell non-Hodgkin's lymphoma.
- RIT has the potential to become an integral part of curative strategies for currently incurable NHL.
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