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Related Experiment Videos

Histopathologic changes in human true vocal folds: a postmortem study.

Ana Karina M Salge1, Luiz César Peres, Marlene A Reis

  • 1Biological Science Department, General Pathology Division, Triângulo Mineiro Federal University, Uberara, Minas Gerais 38025180, Brazil.

Annals of Diagnostic Pathology
|September 19, 2006
PubMed
Summary
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Microscopic lesions of the true vocal cords (TVC) are common in adults, differing from previous descriptions. This study identified frequent TVC morphological changes, including basal membrane thickening and inflammation, revealing a common pathway for various diseases.

Area of Science:

  • Forensic Pathology
  • Otolaryngology
  • Histopathology

Background:

  • Gross pathology of true vocal cords (TVC) is documented, but adult histopathology is scarce, often linked to neoplasia.
  • Existing literature lacks detailed microscopic descriptions of non-neoplastic TVC lesions in adults.

Purpose of the Study:

  • To identify and characterize morphological lesions of the true vocal cords (TVC) in adult autopsy samples.
  • To investigate the frequency and patterns of microscopic TVC alterations in a general adult population.

Main Methods:

  • Cross-sectional study analyzing 266 adult larynxes from 1993-2003.
  • Employed histochemical and immunohistochemical techniques for detailed morphological analysis of TVC.
  • Classified TVC based on microscopic findings, noting presence and type of lesions.

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Main Results:

  • 36.5% of TVC (97/266) were histologically normal.
  • Common lesions included basal membrane thickening (30.5%), inflammatory reactions (24.8%), hemorrhage (7.1%), and ulceration (1.1%).
  • Microscopic TVC lesions were frequent and exhibited diverse morphological patterns not previously described.

Conclusions:

  • Microscopic lesions of the true vocal cords are prevalent in adults and present varied morphological features.
  • The findings challenge existing literature by revealing common, non-neoplastic TVC lesions and a shared pathway for different etiological diseases.
  • This study highlights the importance of histopathological examination for understanding TVC pathology beyond neoplasia.