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Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins

Wanxia He1, Xiangyou Hu, Qi Shi

  • 1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Journal of Molecular Biology
|September 19, 2006
PubMed
Summary

Reticulon 3 (RTN3) inhibits beta-secretase 1 (BACE1) by binding to it, preventing amyloid precursor protein (APP) cleavage. This interaction, dependent on a conserved C-terminal QID motif in RTN3, offers potential for new BACE1-inhibiting drugs.

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