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Related Experiment Video

Updated: Jul 20, 2026

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation
05:25

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation

Published on: December 1, 2023

C4d: a marker for hepatic transplant rejection.

R Lorho1, B Turlin, N Aqodad

  • 1Hôpital de Pontchaillou, Service des Maladies du Foie, CHU Pontchaillou, 35033 Rennes cedex, France. richard.lorho@chu-rennes.fr

Transplantation Proceedings
|September 19, 2006
PubMed
Summary

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C4d deposition in liver transplants can help distinguish acute rejection from hepatitis C recurrence. This finding supports C4d as a reliable biomarker for identifying liver transplant rejection.

Area of Science:

  • Transplantation immunology
  • Gastroenterology
  • Pathology

Background:

  • Acute rejection is a frequent complication following liver transplantation.
  • Diagnosing rejection can be challenging with co-existing hepatitis C virus infection.
  • C4d deposition in portal capillaries may differentiate rejection from hepatitis C recurrence.

Purpose of the Study:

  • To investigate the utility of C4d deposition as a marker for hepatic allograft rejection.
  • To determine if C4d presence aids in differentiating acute rejection from hepatitis C recurrence.

Main Methods:

  • Retrospective analysis of 36 liver transplant biopsies from 34 patients.
  • Biopsies were selected based on suspicion of rejection, hepatitis C recurrence, or routine follow-up.

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Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
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Related Experiment Videos

Last Updated: Jul 20, 2026

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation
05:25

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation

Published on: December 1, 2023

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

  • Immunohistochemical staining for C4d deposition in portal capillaries was performed.

    • Main Results:

    • C4d expression was detected in 33% of acute rejection cases and 100% of chronic rejection cases.
    • No C4d deposition was observed in recurrent hepatitis C infections without rejection.
    • C4d presence correlated significantly with rejection status.

    Conclusions:

    • C4d deposition serves as a valuable marker for identifying acute and chronic rejection in liver allografts.
    • C4d can aid clinicians in differentiating between liver transplant rejection and hepatitis C recurrence.
    • These findings align with existing literature, reinforcing C4d's role in post-transplant liver assessment.