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Related Experiment Videos

Genetic databases and pharmacogenetics: introduction.

Richard E Ashcroft1, Adam M Hedgecoe

  • 1Queen Mary, University of London, Institute of Health Sciences Education, Abernethy Building, 2 Newark Street, London E1 2AT, UK. r.ashcroft@qmul.ac.uk

Studies in History and Philosophy of Biological and Biomedical Sciences
|September 19, 2006
PubMed
Summary
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Large-scale human genetics research, often framed by national prestige and medical progress, faces challenges in demonstrating significant results. The emerging field of pharmacogenetics shows promise, attracting substantial investment and prompting ethical and social scientific inquiry.

Area of Science:

  • Biomedical Sciences
  • Human Genetics
  • Pharmacogenetics
  • Sociology of Science
  • Bioethics

Background:

  • Human genetics research has historically been conducted through large-scale, multidisciplinary 'big science' projects.
  • The legitimacy of these projects is often tied to national prestige, economic benefits, and promises of medical advancement.
  • Despite significant investment, large-scale genetic initiatives have yet to yield widely recognized major results.

Purpose of the Study:

  • To introduce a symposium exploring the ethical and social dimensions of human genetic research.
  • To examine the societal implications of large-scale genetic endeavors and the burgeoning field of pharmacogenetics.

Main Methods:

  • This paper synthesizes sociological, ethical, and philosophical perspectives.

Related Experiment Videos

  • It reviews the discourse surrounding the justification and outcomes of big science in human genetics.
  • Focuses on the growing field of pharmacogenetics as a current area of significant investment and research.

    • Main Results:

    • Large-scale human genetics projects have struggled to meet the objectives used to justify their funding and social support.
    • Pharmacogenetics is identified as a promising area currently attracting substantial industry and government investment.
    • Sociological, ethical, and philosophical studies have evolved alongside biological and biomedical research in this domain.

    Conclusions:

    • The societal and ethical considerations of human genetic research, particularly pharmacogenetics, require parallel scholarly attention.
    • The paper sets the stage for a deeper discussion on the societal impact and ethical frameworks for genetic research.
    • Highlights the need to critically assess the outcomes and justifications for large-scale genetic research initiatives.