Related Experiment Video
Updated: Jul 20, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
A review of skin and the effects of aging on skin structure and function
1Tri-State Wound Care and Hyperbaric Center, Clarkston, WA 99403, USA. docjanep@aol.com
Abstract:
As the most visible and vulnerable organ of the human body, the skin is anatomically and functionally affected by aging. Maintaining skin integrity starts with understanding skin anatomy, physiology, and function and recognizing conditions as well as aspects of care that may affect structure and function. Research suggests that appropriate skin cleansing procedures and protection, as well as nutritional and environmental interventions, may help reduce some of the effects of aging and have positive psychological and health outcomes. Optimizing skin health in the elderly will help maintain its integrity and, as such, should be the first step in any wound prevention program.
Related Concept Videos
The Effect of Aging on Tissues
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Renewal of Skin Epidermal Stem Cells
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Layers of the Epidermis
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...