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Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

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Related Experiment Video

Updated: Jan 18, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Published on: September 5, 2016

Bioinformatics-assisted anti-HIV therapy.

Thomas Lengauer¹, Tobias Sing

¹Max Planck Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany. lengauer@mpi-sb.mpg.de

Nature Reviews. Microbiology

|September 19, 2006

Summary

Highly active antiretroviral therapy (HAART) improves HIV-1 management but drug resistance can cause failure. Bioinformatics tools now aid physicians in selecting effective follow-up regimens based on viral genotype.

Area of Science:

Virology
Bioinformatics
Computational Biology

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