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Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells

Kenichi Miharada1, Takashi Hiroyama, Kazuhiro Sudo

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Nature Biotechnology
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Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...