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Acute Inflammation III: Local and Systemic Effects

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Related Experiment Video

Updated: Jul 20, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
07:26

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Acenocoumarol and vasculitis: a case report.

Karim Aouam1, Azza Gassab, Hassen Khorchani

  • 1Service de Pharmacologie, Faculté de Médecine, Monastir, Tunisia. aouam_k@yahoo.fr

Pharmacoepidemiology and Drug Safety
|September 19, 2006
PubMed
Summary

A rare case of leucocytoclastic vasculitis was observed in a patient taking acenocoumarol. Discontinuing the anticoagulant medication led to the spontaneous resolution of the patient's purpuric skin lesions.

Related Experiment Videos

Last Updated: Jul 20, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
07:26

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Area of Science:

  • Dermatology
  • Internal Medicine
  • Pharmacology

Background:

  • Atrial fibrillation management often involves anticoagulants like acenocoumarol.
  • Drug-induced vasculitis is a recognized but uncommon adverse effect.
  • Early identification of drug-related cutaneous reactions is crucial for patient management.

Observation:

  • A 62-year-old female presented with fever, asthenia, and a purpuric rash on her legs.
  • Symptoms emerged after a 3-day course of acenocoumarol for atrial fibrillation.
  • Skin biopsy confirmed leucocytoclastic vasculitis.

Findings:

  • The patient's lesions resolved spontaneously within 10 days of discontinuing acenocoumarol.
  • A strong temporal association suggests acenocoumarol as the causative agent.
  • Laboratory tests were unremarkable, ruling out other common causes.

Implications:

  • This case highlights a rare association between acenocoumarol and leucocytoclastic vasculitis.
  • Clinicians should consider acenocoumarol as a potential cause of vasculitis.
  • Prompt drug withdrawal is recommended when a temporal link is evident.