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[Decrease of Leu7 positive cells in peripheral blood from patients with aseptic meningitis].

Y Honda1, Y Sato, Y Sato

  • 1Department of Neurology, St. Mary's Hospital.

Rinsho Shinkeigaku = Clinical Neurology
|May 1, 1990
PubMed
Summary
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This study found that people with fewer natural killer (NK) cells may be more susceptible to viral meningitis. Lower NK cell counts were observed in patients during acute aseptic meningitis and even before infection.

Area of Science:

  • Immunology
  • Neuroscience
  • Infectious Diseases

Background:

  • Natural killer (NK) cells play a role in the immune defense against viral infections.
  • The function of NK cells in central nervous system (CNS) infections requires further clarification.

Purpose of the Study:

  • To investigate the role of Leu7 positive natural killer cells in aseptic meningitis and other CNS infections.
  • To determine if NK cell levels correlate with susceptibility to viral meningitis.

Main Methods:

  • Flow cytometry was used to analyze Leu7 positive cells in peripheral blood.
  • Blood samples were collected from patients during the acute phase and after recovery from CNS infections.
  • Patients included those with aseptic meningitis, Japanese encephalitis, fungal meningitis, bacterial meningitis, tuberculous meningitis, and brainstem encephalitis.

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Main Results:

  • Aseptic meningitis patients consistently showed decreased Leu7 positive cells during the acute phase and after recovery compared to normal subjects.
  • These decreased NK cell levels were also suggested to be present before infection.
  • A decrease in positive cells was observed from acute phase to recovery in some Japanese encephalitis and tuberculous meningitis patients, though numbers were too small for statistical significance.

Conclusions:

  • Reduced natural killer cell activity may predispose individuals to viral meningitis.
  • Individuals with inherently lower natural killer cell counts might be more susceptible to developing viral meningitis.
  • Further research is needed to confirm these findings in other CNS infections due to small sample sizes.