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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
[Surveillance on pathogens of meningococcal meningitis in Beijing, 2005]
Tie-gang Zhang1, Xiong He, Li-juan Chen
1Institute of Immunization and Prevention of Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Objective:
To study the pathogens of meningococcal meningitis (MM) in Beijing, 2005.
Methods:
Blood and cerebrospinal fluid specimens from MM patients were detected by polymerase chain reaction. Bacterial strains were analyzed by pulsed-field gel electrophoresis and multilocus sequence typing.
Results:
7 of the blood and 5 of cerebrospinal fluid specimens showed positive results. 105 of the Neisseria meningitides strains were isolated from the specimens of patients, close contacts and healthy carriers. Serogroup A and C Neisseria meningitides strains shared the same patterns of pulsed-fieldgel electrophoresis, respectively. The sequence type of serogroup A Neisseria meningitides belonged to ST7 while the sequence type of serogroup C Neisseria meningitides belonged to ST4821.
Conclusion:
Patients suffered from meningococcal meningitis were caused by serogroup A (ST7) and C (ST4821) Neisseria meningitides in Beijing, 2005.
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