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Updated: Jul 20, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Processing of local and global visual features in obsessive-compulsive disorder.
1University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Clinical Neuropsychology Unit, Hamburg, Germany. moritz@uke.uni-hamburg.de
This study found no evidence of an early local processing bias in obsessive-compulsive disorder (OCD) patients. Performance on hierarchical letter tasks was similar between OCD patients and healthy controls, challenging prior assumptions.
Area of Science:
- Cognitive psychology
- Neuroscience
- Psychiatry
Background:
- Previous research suggested obsessive-compulsive disorder (OCD) patients exhibit a "local bias" in processing complex stimuli.
- This bias implies more efficient processing of local features over global gestalt.
Purpose of the Study:
- To determine if the "local bias" in OCD is present during early stimulus encoding or later processing.
- Investigate the timing of perceptual biases in individuals with OCD.
Main Methods:
- Assessed response to local and global targets using hierarchical letters (e.g., an "E" made of small "T"s).
- Compared performance between 30 OCD patients and 28 healthy controls.
Main Results:
- Obsessive-compulsive disorder patients and healthy controls demonstrated comparable performance across all measured parameters.
- No significant difference was found in the processing of local versus global elements between the groups.
Conclusions:
- The study does not support the hypothesis of an early perceptual bias towards local elements in OCD.
- Further research is needed to explore if local feature bias in OCD is context-dependent, particularly when local and global features compete.
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