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Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Alpha-sheet: The toxic conformer in amyloid diseases?

Valerie Daggett1

  • 1Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195-7610, USA.

Accounts of Chemical Research
|September 20, 2006
PubMed
Summary

Researchers identified a novel protein structure, the alpha-sheet, using molecular dynamics simulations. This structure may play a role in amyloid diseases as a toxic conformer.

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