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Staphylococcus aureus nasal carriage among the diabetic and non-diabetic haemodialysis patients

N Duran1, S Ocak, A F Eskiocak

  • 1Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya Haemodialysis Centre, Hatay, Turkey. nizamduran@hotmail.com

International Journal of Clinical Practice
|September 20, 2006
PubMed

Insights

Staphylococcus aureus nasal carriage is more common in patients on long-term hemodialysis (HD). Antibiotic resistance rates are significantly higher in these HD patients compared to the control group.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Microbiology

Background:

  • Staphylococcus aureus is a leading cause of serious infections in patients undergoing long-term hemodialysis (HD).
  • Methicillin-resistant S. aureus (MRSA) strains are increasingly multidrug-resistant, posing treatment challenges.
  • Understanding S. aureus prevalence and resistance patterns in HD patients is crucial for effective antimicrobial therapy.

Purpose of the Study:

  • To determine the frequency of S. aureus nasal carriage in diabetic and non-diabetic HD patients.
  • To investigate the antimicrobial resistance patterns of S. aureus strains isolated from HD patients.
  • To assess the correlation between HD duration, diabetes mellitus, and S. aureus carriage.

Main Methods:

  • A cross-sectional study involving 261 HD patients and 160 control individuals in Hatay.
  • Screening for S. aureus nasal carriage and assessment of antimicrobial susceptibility profiles.
  • Statistical analysis to identify correlations with HD duration, diabetes mellitus, age, and sex.

Main Results:

  • S. aureus positivity was significantly higher in HD patients (56.7%) compared to controls (16.2%).
  • Longer duration of HD was significantly correlated with S. aureus isolation.
  • Antibiotic resistance rates were significantly higher in S. aureus strains from HD patients than controls.

Conclusions:

  • Nasal carriage of S. aureus is more prevalent in HD patients, with longer HD duration being a risk factor.
  • Diabetes mellitus, age, and sex were not found to be risk factors for S. aureus nasal carriage.
  • HD patients exhibit higher rates of antibiotic resistance in S. aureus, necessitating careful treatment strategies.

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