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High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
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High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

Kinetics of oligonucleotide hybridization to photolithographically patterned DNA arrays

Marc Glazer1, Jacqueline A Fidanza, Glenn H McGall

  • 1Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA. mglazer2@gmail.com <mglazer2@gmail.com>

Analytical Biochemistry
|September 20, 2006
PubMed

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...