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Quasispecies and recombination.

Martin Nilsson Jacobi¹, Mats Nordahl

¹Chalmers University of Technology, Gothenburg, Sweden. mjacobi@chalmers.se

Theoretical Population Biology

|September 20, 2006

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Recombination significantly impacts quasispecies evolution, altering error thresholds and creating dual stable states. At low mutation rates, however, evolution stabilizes around the fittest sequences.

Area of Science:

Evolutionary dynamics
Theoretical biology
Computational biology

Background:

Eigen's quasispecies theory describes viral evolution without recombination.
Understanding the role of recombination is crucial for evolutionary models.

Purpose of the Study:

To investigate the impact of recombination on Eigen's quasispecies theory.
To analyze the effects of recombination on error thresholds and evolutionary dynamics.

Main Methods:

Numerical simulations of rate equations.
Comparison between recombining and non-recombining models.
Mathematical analysis of evolutionary stability.

Main Results:

Recombination introduces two stable fixed points in dynamics for a range of mutation rates.

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Bi-stability leads to the existence of two distinct error thresholds.

At low mutation rates, bi-stability collapses, favoring the fittest sequence.

Conclusions:

Recombination profoundly alters quasispecies evolution and error thresholds.
The dynamics exhibit bi-stability, creating two error thresholds under certain conditions.
Low mutation rates simplify dynamics, concentrating evolution around the highest fitness sequence.